From Lyons:
Highway 7 (AKA S St Vrain) approximately 23 miles. As you pass Camp St Malo on your left, start watching for Nepenthe sign on the right, take that drive, property is first house on the left.
 
From Estes Park:
Highway 7 (AKA S St Vrain) past Charlie Eagle Plumes almost to Camp St Malo, just before you reach the camp take the drive that has the Nepenthe sign, property is first house on the left.